Clomid – Clomifene Citrate 50mg Tablets
Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.
* Keep this leaflet. You may need to read it again.
* If you have any further questions, ask your doctor or pharmacist.
* This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
* If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed int his leaflet.
Clomid (Clomiphene Citrate) is a powerfully effective anti-estrogen officially classified as a Selective Estrogen Receptor Modulator (SERM). In many ways, it is very similar to another popular SERM in Nolvadex (Tamoxifen Citrate). Clomid first gained worldwide attention in the early 1970’s as a strong fertility aid and is still used for that purpose today. It is also one of the most commonly used SERM’s by anabolic steroid users.
No, it is not an anabolic steroid but can be used to combat estrogenic side effects sometimes caused by anabolic steroids. It can also be used as a Post Cycle Therapy (PCT) medication in order to stimulate suppressed testosterone production due to anabolic steroid use. PCT use of Clomid is the most common purpose and most beneficial point of use for the anabolic steroid user.
Functions & Traits
Clomid is a SERM that is specifically used as a fertility aid due to its ability to enhance the release of gonadotropins. Clomid has the ability to oppose the negative feedback of estrogens on the Hypothalamic-Pituitary-Ovarian-Axis.
This will increase the release of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) significantly. By increasing gonadotropin release, this can lead to the egg being released, thereby increasing the chance of conception.
Clomid also carries strong anti-estrogen properties that could be used therapeutically, but its anti-estrogen properties are most commonly associated with anabolic steroid use. Testosterone and many testosterone derived steroids have the ability to convert to estrogen through testosterone’s interaction with the aromatase enzyme.
As estrogen levels rise, this can lead to gynecomastia and excess water retention. Heavy water retention can also promote high blood pressure. By supplementing with Clomid during anabolic steroid use, the SERM will bind to the estrogen receptors, therefore inhibiting the estrogen hormone from binding. This can be very useful in combating gynecomastia, as when Clomid binds to the receptor it prevents estrogen from stimulating the mammary tissue. It can also have a positive impact on water retention, but as it won’t actively reduce serum estrogen levels it’s sometimes not enough.
Clomid also possess functioning traits that are beneficial to the anabolic steroid user
post anabolic steroid use. Specifically we’re referring to Post Cycle Therapy (PCT).
In men, Clomid also has the ability to stimulate the pituitary to release more LH and FSH, which will in turn stimulate enhanced natural testosterone production.
This is extremely beneficial to the anabolic steroid user post cycle as natural testosterone levels will be very low due to suppression caused by anabolic steroid use.
1. What Clomid is and what it is used for
Clomid contains a medicine called clomifene citrate. This belongs to a group of medicines called ovulation stimulants. It works by stimulating the release of eggs from the ovary (ovulation). Clomid is used for some types of infertility, in women who are not ovulating properly.
2. What you need to know before you take
Before you take the medicine talk to your doctor about the risks of:
• Becoming pregnant with more than one child at the same time (multiple pregnancies)
• Pregnancies where the baby grows outside of the womb (ectopic)
• A possible increased risk of ovarian cancer Any pregnancy could lead to birth defects or miscarriage. This can happen even if you are not taking Clomid.
You should talk to your doctor about the possible risks before you take Clomid.
Do not take this medicine and tell your doctor if:
• You are allergic (hypersensitive) to clomifene or any of the other ingredients of Clomid (listed in Section 6 below). Signs of an allergic reaction include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue
• You have or ever had liver disease
• You have unusual menstrual bleeding where the cause is not known
• You have a type of cancer that is made worse by hormones
• You have a cyst on your ovary
• You are pregnant. You should have a test to make sure you are not pregnant before
you take Clomid
Do not take this medicine if any of the above apply to you. Take special care with Clomid.
Check with your doctor or pharmacist before taking your medicine if:
• You are having an early menopause or have been told you are infertile
• You have stopped having periods because you are under-weight
• You have had fits or seizures in the past
• You have ‘fibroids’ in your womb
• You have ‘polycystic’ ovaries
• Your ovaries are swollen
• You have hypertriglyceridemia (an excess of fats in the blood) or a family history of
Your doctor should check for any other causes of fertility problems before starting treatment with Clomid.
If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Clomid.
Taking other medicines
Tell your doctor or pharmacist if you are taking or have recently taken any other medicines.
This includes medicines you buy with a prescription, including herbal medicines.
This is because Clomid can affect the way some other medicines work. Also some medicines can affect the way Clomid works.
Pregnancy and breast-feeding
• Do not take this medicine if you are pregnant or think you may be pregnant
• Talk to your doctor before taking this medicine if you are breast-feeding or planning to breast-feed. Clomid can lower the amount of milk produced.
Ask you doctor or pharmacist for advice before taking any medicine if you are pregnant or breast-feeding.
Driving and using machines
You may notice problems with your eyesight such as blurred vision while taking this medicine. If this happens, do not drive or use any tools or machines.
Clomid contains lactose and sucrose
This medicine contains lactose and sucrose, which are types of sugar. If you have been told by your doctor that you can not tolerate some sugars, talk to your doctor before taking Clomid.
3. How to take
Always take Clomid exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.
Taking this medicine
• Take this medicine by mouth
• Swallow the tablets whole with a drink of water.
• Do not crush or chew your tablets
• Do not take more than two tablets in one day
• Do not take the tablets for more than five days at a time
• If you feel the effect of your medicine is not working, do not change the dose yourself, but ask your doctor
The usual dose is:
Adult women only:
• Your doctor will tell you when in your menstrual cycle to start taking the tablets
• For the first course of treatment, take one tablet a day for five days
• If you do not have a period after the first course of treatment your doctor will increase your dose to two tablets a day for five days
• You should start this second course at least 30 days after the first course
• You will not usually take more than three courses of treatment. If ovulation does not
happen after three courses talk to your doctor
This medicine should not be taken by children, adolescents, men or women who have already gone through the menopause (post-menopausal).
If you take more Clomid than you should, tell a doctor or go to a hospital casualty department straight away. Take the medicine pack with you. This is so the doctor knows what you have taken.
You are likely to get over-stimulation of your ovary (see section 4 below).
If you forget to take Clomid
If you forget a dose, talk to your doctor as you may need to change your treatment cycle. Do not take a double dose to make up for a forgotten tablet.
If you stop taking Clomid
Keep taking Clomid until your doctor tells you to stop. If you stop, the treatment may not work.
If you have any further questions on the use of this product, ask your doctor or pharmacist.
4. Possible side-effects
Like all medicines, Clomid can cause side effects, although not everybody gets them.
Stop taking Clomid and see your doctor or go to a hospital straight away if:
• You have an allergic reaction. The signs may include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue
• You have numbness, weakness or paralysis on one side of your body, slurred speech, sudden blurred vision, confusion or unsteadiness. These could be signs of a stroke.
Stop taking Clomid and see a doctor straight away if you notice any of the following serious side effects – you may need urgent medical treatment:
• Over-stimulation of the ovary. This can lead to pain in the pelvis, stomach or calves, swelling or feeling bloated, passing less urine, difficulty in breathing or an increase in weight. If this happens, your doctor may lower your dose of Clomid
• Blurring of vision or spots or flashes in front of the eyes. These symptoms usually get better but in some cases they may be permanent. Your doctor may send you for an eye examination.
• Liver problems that may cause the eyes or skin to go yellow (jaundice)
• Sudden and severe headaches
• Mental illness such as ‘psychosis’
Tell your doctor or pharmacist if any of the following side effects get serious or lasts
longer than a few days:
• Increased pain with periods, heavy periods or bleeding between periods
• Pain in the lower part of the stomach. This could be a sign of endometriosis or worsening of endometriosis, ovarian cancer or enlarged ovaries
• Thinning of the layer covering the inside of the uterus.
• Increased levels of fat in the blood (hypertriglyceridaemia) which may also cause inflammation of the pancreas.
• Pain in the upper middle or upper left part of the abdomen. This could be a sign of
inflammation of the pancreas pancreatitis).
• Cloudy lenses in the eye (cataracts)
• Fits, feeling faint, disorientated or more tense than normal. Also, balance problems or feeling dizzy (vertigo)
• Feeling tired or difficulty in sleeping (insomnia), depression or change in moods or behaviour
• Speech problems
• Skin rash or itching
• Feeling or being sick
• Flushing of the skin
• Swelling of the face, around the eyes, lips or tongue
• Painful breasts
• Hair loss or thinning
• Increased levels of liver enzymes shown up in blood tests. This can mean that your
liver is not working properly.
• Numbness or tingling on your skin (paraesthesia)
• Feeling anxious
• Feeling more nervous than usual.
There have been rare reports of ovarian cancer with fertility drugs. Some studies suggest that prolonged use of clomifene may increase this risk. Therefore the recommended duration of treatment should not be exceeded.
Talk to your doctor or pharmacist if any of the side effects gets serious or lasts longer than a few days or if you notice any side effects not listed in this leaflet.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in the leaflet.
5. How to store
Keep out of sight and reach of children.
Store in the original container below 25°C.
Do not use Clomid after the expiry date which is stated on the carton. The expiry date refers to the last day of that month.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
6. Contents of the pack and other information
What Clomid contains
• Each tablet contains 50mg of the active substance, clomifene citrate
• The other ingredients are sucrose, lactose, soluble starch, maize starch, magnesium
stearate, iron oxide yellow (E172), purified water
What Clomid looks like and contents of the pack Clomid 50mg Tablets are white and round, they are supplied in PVC and aluminium blister packs. Pack sizes 28 tablets.